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Article

Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma

4 Apr 2018

Abstract excerpt

We generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using mass cytometry. Data-driven analyses of these high-resolution single-cell data identified 2 distinct immunologic subtypes of MPM with vastly different cellular composition, activation states, and immunologic function; mass spectrometry demonstrated differential abundance of MHC-I and -II...

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PMID: 29618661
DOI: 10.1172/jci.insight.98575

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