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Article

The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer.

PloS one - 12 Jun 2009

Basak Saroj K, Veena Mysore S, Oh Scott, Huang Ge, Srivatsan Eri, Huang Min, Sharma Sherven, Batra Raj K

Abstract excerpt

Malignant Pleural Effusions (MPE) may be useful as a model to study hierarchical progression of cancer and/or intratumoral heterogeneity. To strengthen the rationale for developing the MPE-model for these purposes, we set out to find evidence for the presence of cancer stem cells (CSC) in MPE and demonstrate an ability to sustain intratumoral heterogeneity in MPE-primary cultures. Our studies show that candidate...

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Identifiers

PMID: 19536353
DOI: 10.1371/journal.pone.0005884
PMCID: PMC2697051

Genes

MET
PTEN
SUZ12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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