Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment.

doi:10.1158/1078-0432.CCR-20-1767

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2020

Chen Runzhe, Lee Won-Chul, Fujimoto Junya, Li Jun, Hu Xin, Mehran Reza, Rice David, Swisher Stephen G, Sepesi Boris, Tran Hai T, Chow Chi-Wan, Little Latasha D, Gumbs Curtis, Haymaker Cara, Heymach John V, Wistuba Ignacio I, Lee J Jack, Futreal P Andrew, Zhang Jianhua, Reuben Alexandre, Tsao Anne S, Zhang Jianjun

Abstract excerpt

PURPOSE: Malignant pleural mesothelioma (MPM) is considered an orphan disease with few treatment options. Despite multimodality therapy, the majority of MPMs recur and eventually become refractory to any systemic treatment. One potential mechanism underlying therapeutic resistance may be intratumor heterogeneity (ITH), making MPM challenging to eradicate. However, the ITH architecture of MPM and its clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dasatinib

Share to Exome Sequencing

Share to Genetic Heterogeneity

Share to Mesothelioma, Malignant

Share to Neoplasm Recurrence, Local

Share to Progression-Free Survival

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 32816946
DOI: 10.1158/1078-0432.CCR-20-1767
PMCID: PMC7709879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment.PMID 32816946Read ↗

Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesotheliomaSemantic proximity Read ↗

Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma.Semantic proximity Read ↗

Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesotheliomaSemantic proximity Read ↗

Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular LandscapeSemantic proximity Read ↗

Immune Microenvironment and Genetics in Malignant Pleural MesotheliomaSemantic proximity Read ↗

Interrogating inter- and intratumour genomic heterogeneity in mesotheliomaSemantic proximity Read ↗

The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel SequencingSemantic proximity Read ↗

Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.Semantic proximity Read ↗

Integrative Molecular Characterization of Malignant Pleural Mesothelioma.Semantic proximity Read ↗

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneitySemantic proximity Read ↗

Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classificationSemantic proximity Read ↗

Integrated genomics identify novel immunotherapy targets for malignant mesotheliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.