Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity.

doi:10.1186/s12967-016-0816-x

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Article

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity.

Journal of translational medicine - 29 Feb 2016

Roscilli Giuseppe, De Vitis Claudia, Ferrara Fabiana Fosca, Noto Alessia, Cherubini Emanuela, Ricci Alberto, Mariotta Salvatore, Giarnieri Enrico, Giovagnoli Maria Rosaria, Torrisi Maria Rosaria, Bergantino Francesca, Costantini Susan, Fenizia Francesca, Lambiase Matilde, Aurisicchio Luigi, Normanno Nicola, Ciliberto Gennaro, Mancini Rita

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of cancer related deaths and Malignant Pleural Effusion (MPE) is a frequent complication. Current therapies suffer from lack of efficacy in a great percentage of cases, especially when cancer is diagnosed at a late stage. Moreover patients' responses vary and the outcome is unpredictable. Therefore, the identification of patients who will benefit most of chemotherapy...

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PMID: 26928703
DOI: 10.1186/s12967-016-0816-x
PMCID: PMC4772534

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