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Article

Modulation of TRPV-1 by prostaglandin-E2 and bradykinin changes cough sensitivity and autonomic regulation of cardiac rhythm in healthy subjects.

Scientific reports - 16 Sept 2020

Liviero Filippo, Scarpa Maria Cristina, De Stefani Diego, Folino Franco, Campisi Manuela, Mason Paola, Iliceto Sabino, Pavanello Sofia, Maestrelli Piero

Abstract excerpt

A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs)....

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Identifiers

PMID: 32938990
DOI: 10.1038/s41598-020-72062-y
PMCID: PMC7494872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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