Article
Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP.
Chemical research in toxicology - 20 Jun 2011
Deering-Rice Cassandra E, Romero Erin G, Shapiro Darien, Hughen Ronald W, Light Alan R, Yost Garold S, Veranth John M, Reilly Christopher A
Abstract excerpt
Inhalation of environmental particulate matter (PM) is correlated with adverse health effects in humans, but gene products that couple detection with cellular responses, and the specific properties of PM that target different pathways, have not been fully elucidated. TRPA1 and V1 are two cation channels expressed by sensory neurons and non-neuronal cells of the respiratory tract that have been implicated as...
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