Article
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.
Pharmacological reviews - 1 Oct 2020
Norel Xavier, Sugimoto Yukihiko, Ozen Gulsev, Abdelazeem Heba, Amgoud Yasmine, Bouhadoun Amel, Bassiouni Wesam, Goepp Marie, Mani Salma, Manikpurage Hasanga D, Senbel Amira, Longrois Dan, Heinemann Akos, Yao Chengcan, Clapp Lucie H
Abstract excerpt
Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved in the regulation of homeostasis and main physiologic functions. In addition, the synthesis of these two prostaglandins is significantly increased during inflammation. PGI2 and PGE2 exert their biologic actions by binding to their respective...
Topics
- Animals
- Autoimmune Diseases
- Dinoprostone
- Epoprostenol
- Humans
- Inflammation
- Mice
- Polymorphism, Single Nucleotide
- Protein Multimerization