Channel synapse mediates neurotransmission of airway protective chemoreflexes

Abstract excerpt

Neural reflexes to chemicals in the throat protect the airway from aspiration and infection. Mechanistic understanding of these reflexes remains premature, exemplified by chronic cough—a sensitized cough reflex—being a prevalent unmet clinical need. Here, in mice, a whole-body search for channel synapses—featuring CALHM1/3 channel-mediated neurotransmitter release—and single-cell transcriptomics uncovered...

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• Biochemical Analysis and Sensing Techniques
• Neuroscience of respiration and sleep
• Respiratory and Cough-Related Research