Article
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart.
Nature communications - 16 Sept 2020
Guo Haipeng, Lu Yao Wei, Lin Zhiqiang, Huang Zhan-Peng, Liu Jianming, Wang Yi, Seok Hee Young, Hu Xiaoyun, Ma Qing, Li Kathryn, Kyselovic Jan, Wang Qingchuan, Lin Jenny L-C, Lin Jim J-C, Cowan Douglas B, Naya Francisco, Chen Yuguo, Pu William T, Wang Da-Zhi
Abstract excerpt
Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular diseases. Here, we show that loss of Xinβ, a newly-identified component of ICDs, results in cardiomyocyte proliferation defects and cardiomyopathy. We uncovered a role...
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