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Article

Xin proteins and intercalated disc maturation, signaling and diseases

1 Jan 2012

Abstract excerpt

Intercalated discs (ICDs) are cardiac-specific structures responsible for mechanical and electrical communication among adjacent cardiomyocytes and are implicated in signal transduction. The striated muscle-specific Xin repeat-containing proteins localize to ICDs and play critical roles in ICD formation and cardiac function. Knocking down the Xin gene in chicken embryos collapses the wall of developing heart...

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Identifiers

PMID: 22652799
DOI: 10.2741/4072

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Related research

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Research trail→

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Xin proteins and intercalated disc maturation, signaling and diseasesPMID 22652799Read ↗

New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease.Semantic proximity Read ↗

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Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defectsSemantic proximity Read ↗

Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.Semantic proximity Read ↗

Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.Semantic proximity Read ↗

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Repression of <i>Pdzrn3</i> is required for heart maturation and protects against heart failureSemantic proximity Read ↗

The<i>Drosophila</i>muscle LIM protein, Mlp84B, is essential for cardiac functionSemantic proximity Read ↗

Intercalated disc protein, mXinα, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin.Semantic proximity Read ↗

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The role of the M-band myomesin proteins in muscle integrity and cardiac diseaseSemantic proximity Read ↗

Refining the molecular organization of the cardiac intercalated disc.Semantic proximity Read ↗

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