Article
Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy.
Experimental cell research - 15 Oct 2016
Kebir Sied, Orfanos Zacharias, Schuld Julia, Linhart Markus, Lamberz Christian, van der Ven Peter F M, Schrickel Jan, Kirfel Gregor, Fürst Dieter O, Meyer Rainer
Abstract excerpt
Pressure overload induces cardiac remodeling involving both the contractile machinery and intercalated disks (IDs). Filamin C (FlnC) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adapters localizing in IDs of higher vertebrates. Knockout of the gene encoding Xin (Xirp1) in mice leads to a mild cardiac phenotype with ID mislocalization. In order to amplify this phenotype, we performed...
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