Article
Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.
Cardiovascular research - 1 Mar 2010
Otten Julia, van der Ven Peter F M, Vakeel Padmanabhan, Eulitz Stefan, Kirfel Gregor, Brandau Oliver, Boesl Michael, Schrickel Jan W, Linhart Markus, Hayess Katrin, Naya Francisco J, Milting Hendrik, Meyer Rainer, Fürst Dieter O
Abstract excerpt
AIMS: Xin is a striated muscle-specific F-actin binding protein that has been implicated in cardiomyopathies. In cardiomyocytes, Xin is localized at intercalated discs (IDs). Mice lacking only two of the three Xin isoforms (XinAB(-/-) mice) develop severe cardiac hypertrophy. To further investigate the function of Xin variants in the mammalian heart, we generated XinABC(-/-) mice deficient in all Xin isoforms....
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