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Article

Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity.

Thrombosis research - 1 Jun 2013

Nahar Risha, Dube Divya, Parakh Rajiv, Deb Roumi, Saxena Renu, Singh Tej P, Verma Ishwar C

Abstract excerpt

INTRODUCTION: Polymorphisms in CYP2C9 can vary the rate of metabolic clearance of oral anticoagulants, risking toxicity in patients. The present study focused on exploring the genetic etiology of idiopathic hyper sensitivity to coumarin anticoagulants in a patient who presented with multiple bleeding episodes and supra-elevated International Normalized Ratios. MATERIALS AND METHODS: Bidirectional gene sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23582453
DOI: 10.1016/j.thromres.2013.03.019

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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