Article
Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.
Clinical and experimental pharmacology & physiology - 1 Dec 2017
Rao Durga Koteswara, Murthy Dwaraknath K, Shaik Nazia Sultana, Banaganapalli Babajan, Konda Kumaraswami, Rao Hanmantha P, Ganti Eswar, Ahmed Awan Zuhair, A El-Harouni Ashraf, Elango Ramu, Ali Khan Imran, Shaik Noor Ahmad
Abstract excerpt
The CYP2C8 and CYP2C9 are two major isoforms of the cytochrome P450 enzyme family, which is involved in drug response, detoxification, and disease development. This study describes the differential distribution of amino acid substitution variants of CYP2C8 (*2-I269F & *3-R139K) and CYP2C9 (*2-C144R & *3-L359A) genes in 234 type 2 diabetes mellitus (T2DM) patients and 218 healthy controls from Andhra Pradesh,...
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