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Article

Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.

The American journal of pathology - 1 Dec 2020

Parrilla Castellar Edgardo R, Plichta Jennifer K, Davis Richard, Gonzalez-Hunt Claudia, Sanders Laurie H

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson disease. Although LRRK2-related Parkinson disease patients have a heightened risk of certain nonskin cancers, including breast cancer, it is unknown whether LRRK2 somatic mutations occur and are associated with breast cancer. The objective of this study was to evaluate the occurrence of LRRK2 somatic...

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Identifiers

PMID: 32931768
DOI: 10.1016/j.ajpath.2020.08.010

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