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The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities

29 Jul 2020

Abstract excerpt

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes. These include factors that have been associated with all the hallmarks of cancer, from genomic instability to increased proliferation and...

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PMID: 32751160
DOI: 10.3390/cancers12082106

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