Article
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
Nature genetics - 1 Jan 2010
Veeriah Selvaraju, Taylor Barry S, Meng Shasha, Fang Fang, Yilmaz Emrullah, Vivanco Igor, Janakiraman Manickam, Schultz Nikolaus, Hanrahan Aphrothiti J, Pao William, Ladanyi Marc, Sander Chris, Heguy Adriana, Holland Eric C, Paty Philip B, Mischel Paul S, Liau Linda, Cloughesy Timothy F, Mellinghoff Ingo K, Solit David B, Chan Timothy A
Abstract excerpt
Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common cause of early-onset Parkinson's disease. In a search for multisite tumor suppressors, we identified PARK2 as a frequently targeted gene on chromosome 6q25.2-q27 in cancer. Here we describe inactivating somatic mutations and frequent intragenic deletions of PARK2 in human malignancies. The PARK2 mutations in cancer occur in the...
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