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Article

Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.

Scientific reports - 22 Jan 2021

Lebovitz Chandra, Wretham Nicole, Osooly Maryam, Milne Katy, Dash Tia, Thornton Shelby, Tessier-Cloutier Basile, Sathiyaseelan Paalini, Bortnik Svetlana, Go Nancy Erro, Halvorsen Elizabeth, Cederberg Rachel A, Chow Norman, Dos Santos Nancy, Bennewith Kevin L, Nelson Brad H, Bally Marcel B, Lam Wan L, Gorski Sharon M

Abstract excerpt

Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson's disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is associated with lung adenocarcinoma (LUAD). The clinical and functional relevance of LRRK2 repression in LUAD is unknown. Here, we investigated associations between LRRK2...

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Identifiers

PMID: 33483550
DOI: 10.1038/s41598-021-81639-0
PMCID: PMC7822882

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