Article
Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2012
Sikosek Tobias, Chan Hue Sun, Bornberg-Bauer Erich
Abstract excerpt
A fundamental question in molecular evolution is how proteins can adapt to new functions while being conserved for an existing function at the same time. Several theoretical models have been put forward to explain this apparent paradox. The most popular models include neofunctionalization, subfunctionalization (SUBF) by degenerative mutations, and dosage models. All of these models focus on adaptation after gene...
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