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Article

Fitness conferred by replaced amino acids declines with time.

Biology letters - 23 Oct 2012

Naumenko Sergey A, Kondrashov Alexey S, Bazykin Georgii A

Abstract excerpt

The fitness landscape of a locus, the array of fitnesses conferred by its alleles, can be affected by allele replacements at other loci, in the presence of epistatic interactions between loci. In a pair of diverging homologous proteins, the initially high probability that an amino acid replacement in one of them will make it more similar to the other declines with time, implying that the fitness landscapes of...

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Identifiers

PMID: 22628094
DOI: 10.1098/rsbl.2012.0356
PMCID: PMC3440982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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