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Article

Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.

European journal of pharmacology - 5 Nov 2020

Gan Yu-Miao, Liu Dong-Ling, Chen Chu, Duan Wei, Yang Yu-Xin, Du Jun-Rong

Abstract excerpt

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the...

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Identifiers

PMID: 32926919
DOI: 10.1016/j.ejphar.2020.173552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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