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Article

Candesartan modulates microglia activation and polarization via NF-κB signaling pathway.

International journal of immunopathology and pharmacology - 1 Jan 2000

Qie Shuyan, Ran Yuanyuan, Lu Xiaosheng, Su Wei, Li Wei, Xi Jianing, Gong Weijun, Liu Zongjian

Abstract excerpt

Microglia are diverse cells that acquire different functional phenotypes in response to microenvironment in which they reside. Several transcriptional regulators have been identified that regulate different microglia phenotypes. They are mainly stimulated into two opposing phenotypes, classically (M1) and alternatively (M2) phenotype. Regulating microglia polarization from M1 to M2 state has been suggested as a...

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PMID: 33237822
DOI: 10.1177/2058738420974900
PMCID: PMC7691946

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