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Article

Docosahexaenoic acid promotes M2 microglia phenotype via activating PPARγ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury.

Brain research bulletin - 1 Jul 2023

Lv Huijing, Jia Shuai, Sun Yanan, Pang Meng, Lv E, Li Xiangling, Meng Qinghui, Wang Yanqiang

Abstract excerpt

In ischemia-reperfusion stroke, microglia play a dual role in brain injury as well as brain repair, and promoting their switch from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype is considered to be a potential therapeutic strategy. Docosahexaenoic acid (DHA) is an essential long-chain omega-3 polyunsaturated fatty acid that exhibits potent anti-inflammatory properties in the acute phase of...

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PMID: 37149267
DOI: 10.1016/j.brainresbull.2023.110660

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