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The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice.

CNS neuroscience & therapeutics - 1 Jan 2021

Lei Xia, Li Hanxia, Li Min, Dong Qiwei, Zhao Huayang, Zhang Zongyong, Sun Baoliang, Mao Leilei

Abstract excerpt

The aim of present study was to explore whether 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO)-ethylamide (CDDO-EA) attenuates cerebral ischemic injury and its possible mechanisms using a middle cerebral artery occlusion (MCAO) model in C57BL/6 mice. Our results showed that intraperitoneal injection (i.p.) of CDDO-EA (2 and 4 mg/kg) augmented NFE2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33280237
DOI: 10.1111/cns.13496
PMCID: PMC7804925

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