Article
Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations.
International journal of obesity (2005) - 1 Jan 2021
Trier Cæcilie, Hollensted Mette, Schnurr Theresia M, Lund Morten Asp Vonsild, Nielsen Tenna Ruest Haarmark, Rui Gao, Andersson Ehm Astrid, Svendstrup Mathilde, Bille Dorthe Sadowa, Gjesing Anette P, Fonvig Cilius Esmann, Frithioff-Bøjsøe Christine, Balslev-Harder Marie, Quan Shi, Gamborg Michael, Pedersen Oluf, Ängquist Lars, Holm Jens-Christian, Hansen Torben
Abstract excerpt
OBJECTIVES: To determine the prevalence of Melanocortin-4 Receptor (MC4R) mutations in a cohort of children and adolescents with overweight or obesity and to determine whether treatment responses differed between carriers and noncarriers. METHODS: Using target region capture sequencing, an MC4R mutation screen was performed in 1261 Danish children and adolescents enrolled at a tertiary multidisciplinary childhood...
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