Article
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.
The Journal of clinical endocrinology and metabolism - 1 May 2006
Lubrano-Berthelier Cecile, Dubern Beatrice, Lacorte Jean-Marc, Picard Franck, Shapiro Astrid, Zhang Sumei, Bertrais Sandrine, Hercberg Serge, Basdevant Arnaud, Clement Karine, Vaisse Christian
Abstract excerpt
CONTEXT: Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene are the most common monogenic form of severe obesity in children. There are conflicting reports regarding the prevalence, nature, and pathogenic effects of MC4R mutations in adults with severe late-onset obesity. OBJECTIVE: Our objective was to determine the prevalence of MC4R mutations in a cohort of severely obese adults and to determine...
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