Article
Mutations in melanocortin-4 receptor and human obesity.
Progress in molecular biology and translational science - 1 Jan 2009
Tao Ya-Xiong
Abstract excerpt
Multiple lines of investigations demonstrated that the melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis from fishes to humans. Clinical studies in humans showed that mutations in the MC4R gene are the most prevalent form of monogenic obesity. More than 150 mutations have been identified from subjects of different ethnic backgrounds. Functional analyses of the mutant MC4Rs revealed...
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