Article
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.
The Journal of clinical endocrinology and metabolism - 1 Sept 2007
Hainerová Irena, Larsen Lesli H, Holst Birgitte, Finková Marie, Hainer Vojtech, Lebl Jan, Hansen Torben, Pedersen Oluf
Abstract excerpt
BACKGROUND: Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common known cause of monogenic human obesity. AIMS: The aims of this study were the following: 1) to estimate the prevalence of MC4R mutations in obese Czech children; 2) to evaluate phenotypic features of the mutation carriers; 3) to compare weight, height, and body mass index of MC4R mutation carriers with noncarriers in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.