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Melanocortin 4 receptor mutation in obesity

29 Oct 2024

Abstract excerpt

Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R) which suppress appetite and increase energy expenditure. MC4R...

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PMID: 39713072
DOI: 10.5493/wjem.v14.i4.99239

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