Article
Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents.
Journal of clinical research in pediatric endocrinology - 1 Sept 2017
Tunç Selma, Demir Korcan, Tükün Fatma Ajlan, Topal Cihan, Hazan Filiz, Sağlam Burcu, Nalbantoğlu Özlem, Yıldız Melek, Özkan Behzat
Abstract excerpt
OBJECTIVE: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity. Data regarding MC4R mutations in Turkish subjects are limited. To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents. METHODS: MC4R was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1-18 years) who presented...
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