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Article

Intra-tumoral heterogeneity and immune responses predicts prognosis of gastric cancer.

Aging - 26 Nov 2020

Feng Wanjing, Wang Yue, Chen Siyuan, Zhu Xiaodong

Abstract excerpt

Chemotherapy resistance eventually develops in patients with gastric cancer (GC). Intra-tumoral heterogeneity (ITH) refers to the intercellular genetic variations and phenotypic diversity that affect responses to drug therapy. We measured ITH using mutant-allele tumor heterogeneity (MATH) derived from whole-exome sequencing data of patients with GC in The Cancer Genome Atlas (TCGA) database. The study included...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33259333
DOI: 10.18632/aging.202238
PMCID: PMC7762511

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