Article
Tumor Mutation Burden and Structural Chromosomal Aberrations Are Not Associated with T-cell Density or Patient Survival in Acral, Mucosal, and Cutaneous Melanomas.
Cancer immunology research - 1 Nov 2020
Edwards Jarem, Ferguson Peter M, Lo Serigne N, Pires da Silva Inês, Colebatch Andrew J, Lee Hansol, Saw Robyn P M, Thompson John F, Menzies Alexander M, Long Georgina V, Newell Felicity, Pearson John V, Waddell Nicola, Hayward Nicholas K, Johansson Peter A, Mann Graham J, Scolyer Richard A, Palendira Umaimainthan, Wilmott James S
Abstract excerpt
Tumor mutation burden (TMB) has been proposed as a key determinant of immunogenicity in several cancers, including melanoma. The evidence presented thus far, however, is often contradictory and based mostly on RNA-sequencing data for the quantification of immune cell phenotypes. Few studies have investigated TMB across acral, mucosal, and cutaneous melanoma subtypes, which are known to have different TMB. It is...
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