Gene expression and immune infiltration in melanoma patients with different mutation burden.

doi:10.1186/s12885-021-08083-1

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Article

Gene expression and immune infiltration in melanoma patients with different mutation burden.

BMC cancer - 9 Apr 2021

Wang Liwei, Chen Fu, Liu Rui, Shi Lei, Zhao Guosheng, Yan Zhengjian

Abstract excerpt

BACKGROUND: Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one of the essential factors that affect immunotherapeutic efficacies, but it has not been determined whether the mutation is associated with the survival of Skin Cutaneous Melanoma (SKCM) patients....

Topics

Aged
Algorithms
Biomarkers, Tumor
Databases, Genetic
Disease Susceptibility
Female
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
Lymphocytes, Tumor-Infiltrating
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma

Middle Aged

Mutation

Neoplasm Grading

Neoplasm Metastasis

Neoplasm Staging

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33836680
DOI: 10.1186/s12885-021-08083-1
PMCID: PMC8034108

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