Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.

doi:10.1136/jmedgenet-2020-106830

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Article

Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.

Journal of medical genetics - 1 Oct 2021

Zhang Yan, Li Shiwu, Li Xiaoyan, Yang Yongfeng, Li Wenqiang, Xiao Xiao, Li Ming, Lv Luxian, Luo XiongJian

Abstract excerpt

The association between NOTCH4 and schizophrenia has been repeatedly reported. However, the results from different genetic studies are inconsistent, and the role of NOTCH4 in schizophrenia pathogenesis remains unknown. Here, we provide convergent lines of evidence that support NOTCH4 as a schizophrenia risk gene. We first performed a meta-analysis and found that a genetic variant (rs2071287) in NOTCH4 was...

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PMID: 32900838
DOI: 10.1136/jmedgenet-2020-106830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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