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Article

Is NOTCH4 associated with schizophrenia?

Psychiatric genetics - 1 Mar 2004

Zhang Xuan, Wei Jun, Yu Ya-Qin, Liu Shu-Zheng, Shi Jie-Ping, Liu Lin-Lin, Ju Gui-Zhi, Yang Jian-Zhong, Zhang Dai, Xu Qi, Shen Yan, Hemmings Gwynneth P

Abstract excerpt

The NOTCH4 locus was reported to be associated with schizophrenia in our previous study but the subsequent replication by other workers has been inconsistent. To find out possible reasons for the poor replication, the present work was undertaken to analyse four functional single nucleotide polymorphisms (SNPs) (rs367398, rs915894, rs520692 and rs422951) at the NOTCH4 locus among 141 schizophrenic family trios of...

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Source

Identifiers

PMID: 15091315
DOI: 10.1097/00041444-200403000-00007

Genes

NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Is NOTCH4 associated with schizophrenia?PMID 15091315Read ↗

A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

A re-review of the association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples.Semantic proximity Read ↗

Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses.Semantic proximity Read ↗

Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.Semantic proximity Read ↗

NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder.Semantic proximity Read ↗

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.Semantic proximity Read ↗

The NOTCH4 locus is associated with susceptibility to schizophrenia.Semantic proximity Read ↗

A family-based and case-control association study of the NOTCH4 gene and schizophrenia.Semantic proximity Read ↗

Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population.Semantic proximity Read ↗

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland.Semantic proximity Read ↗

Genetic association between Notch4 polymorphisms and Japanese schizophrenics.Semantic proximity Read ↗

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