Article
Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples.
Biological psychiatry - 15 Jul 2003
Takahashi Sakae, Cui Yu-hu, Kojima Takuya, Han Yong-hua, Yu Shun-ying, Tanabe Eiici, Yara Kazuo, Matsuura Masato, Matsushima Eisuyke, Nakayama Junko, Arinami Tadao, Shen Yu-cun, Faraone Stephen V, Tsuang Ming T
Abstract excerpt
BACKGROUND: A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding. METHODS: We performed a family based association study of NOTCH4 and schizophrenia in 123 trios (16 Japanese and 107 Chinese). In addition to the original study's polymorphisms, we examined four new single nucleotide...
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