Article
A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2006
Wang Zhenqi, Wei Jun, Zhang Xuan, Guo Yingjun, Xu Qi, Liu Shuzheng, Shi Jieping, Yu Yaqin, Ju Guizhi, Li Yulin, Shen Yan
Abstract excerpt
This work reviewed all the reports on the NOTCH4 gene in schizophrenia, which have been published since the gene was found to be associated with illness among a British population in 2000. The results from independent studies were inconsistent. Allelic heterogeneity, clinical diagnosis, ethnical backgrounds, and linkage disequilibrium (LD) structures in the human genome may be major reasons for poor replication....
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