Article
No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.
Psychiatric genetics - 1 Oct 2006
Ivo Roland, Schulze Thomas G, Schumacher Johannes, Kesper Kristina, Müller Daniel J, Kremer Ilana, Dobrusin Michael, Mujaheed Mustafa, Murad Ibrahim, Blanaru Monika, Bannoura Isaam, Reshef Alon, Bachner-Melman Rachel, Ebstein Richard P, Propping Peter, Belmaker Robert H, Maier Wolfgang, Rietschel Marcella, Nöthen Markus M, Cichon Sven
Abstract excerpt
OBJECTIVES: An analysis of 80 British parent-offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. METHODS: Our study population comprised a German case-control sample (n=512 schizophrenia patients and n=232...
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