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Article

The NOTCH4 locus is associated with susceptibility to schizophrenia.

Nature genetics - 1 Aug 2000

Wei J, Hemmings G P

Abstract excerpt

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

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Source

Identifiers

PMID: 10932176
DOI: 10.1038/78044

Genes

NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NOTCH4 locus is associated with susceptibility to schizophrenia.PMID 10932176Read ↗

A re-review of the association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

Identification of novel single nucleotide polymorphisms within the NOTCH4 gene and determination of association with MHC alleles.Semantic proximity Read ↗

Is NOTCH4 associated with schizophrenia?Semantic proximity Read ↗

Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.Semantic proximity Read ↗

A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples.Semantic proximity Read ↗

A family-based and case-control association study of the NOTCH4 gene and schizophrenia.Semantic proximity Read ↗

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.Semantic proximity Read ↗

Association of the NOTCH4 Gene Polymorphism rs204993 with Schizophrenia in the Chinese Han Population.Semantic proximity Read ↗

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland.Semantic proximity Read ↗

NOTCH4 gene haplotype is associated with schizophrenia in African Americans.Semantic proximity Read ↗

Up-regulation of NOTCH4 gene expression in bipolar disorder.Semantic proximity Read ↗

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