Article
Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan.
International journal of molecular sciences - 3 Sept 2020
Mbah Ntepe Leonel Javeres, Habib Rabia, Judith Laure Ngondi, Raza Saqlain, Nepovimova Eugenie, Kuca Kamil, Batool Sajida, Muhammad Nurulain Syed
Abstract excerpt
The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. However, several studies have shown that AChE inhibition alone cannot explain all the toxicological manifestations in prolonged exposure to OPs. The present study aimed to assess the status of antioxidants malondialdehyde (MDA), superoxide...
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