Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of IFNL4 in liver inflammation and progression of fibrosis.

Genes and immunity - 1 Jun 2022

Møhlenberg Michelle, O'Brien Thomas R, Hartmann Rune

Abstract excerpt

The discovery that genetic variation within the interferon lambda locus has a profound effect on the outcome of hepatitis C virus (HCV) treatment and spontaneous clearance of HCV is one of the great triumphs of genomic medicine. Subsequently, the IFNL4 gene was discovered and proposed as the causal gene underlying this association. However, there has been a lively debate within the field concerning the causality,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibrosis
Share to Genotype
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Inflammation

Share to Interferons

Share to Interleukins

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 35585257
DOI: 10.1038/s41435-022-00173-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of IFNL4 in liver inflammation and progression of fibrosis.PMID 35585257Read ↗

IFNL4: Notable variants and associated phenotypes.Semantic proximity Read ↗

Genetics of the Human Interferon Lambda RegionSemantic proximity Read ↗

Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections.Semantic proximity Read ↗

Innate and adaptive genetic pathways in HCV infection.Semantic proximity Read ↗

IFN-λ4: the paradoxical new member of the interferon lambda family.Semantic proximity Read ↗

The IFNL4 Gene Is a Noncanonical Interferon Gene with a Unique but Evolutionarily Conserved RegulationSemantic proximity Read ↗

Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.Semantic proximity Read ↗

Interferon lambda 4 expression is suppressed by the host during viral infectionSemantic proximity Read ↗

Host - hepatitis C viral interactions: The role of genetics.Semantic proximity Read ↗

Identifying causal variants at the interferon lambda locus in case-control studies: Utilizing non-synonymous variant rs117648444 to probe the role of IFN-λ4.Semantic proximity Read ↗

Interferon lambda 4 impacts the genetic diversity of hepatitis C virusSemantic proximity Read ↗

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.