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Article

Polygenic architecture informs potential vulnerability to drug-induced liver injury.

Nature medicine - 1 Oct 2020

Koido Masaru, Kawakami Eri, Fukumura Junko, Noguchi Yui, Ohori Momoko, Nio Yasunori, Nicoletti Paola, Aithal Guruprasad P, Daly Ann K, Watkins Paul B, Anayama Hisashi, Dragan Yvonne, Shinozawa Tadahiro, Takebe Takanori

Abstract excerpt

Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effects of numerous genome-wide loci identified from previous large-scale genome-wide association studies2. The PRS...

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Identifiers

PMID: 32895570
DOI: 10.1038/s41591-020-1023-0
PMCID: PMC8482794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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