Article
Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity.
The pharmacogenomics journal - 22 May 2018
Sutherland J J, Webster Y W, Willy J A, Searfoss G H, Goldstein K M, Irizarry A R, Hall D G, Stevens J L
Abstract excerpt
Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based approaches for genomic analysis help overcome challenges with whole-genome transcriptional profiling using limited numbers of treatments for phenotypes of interest. Herein, we apply co-expression network analysis to safety assessment using rat liver gene expression...
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