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Genetic and Genomic Approaches to the Study of Drug-Induced Liver Injury.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jan 2025

Daly Ann K

Abstract excerpt

Idiosyncratic hepatotoxicity induced by prescribed drugs has been known since the early 20th century. Identifying risk factors, including genetic factors, that trigger this drug-induced liver injury (DILI) has been an important priority for many years, both to prevent drugs that cause liver injury being licensed and as a potential means of preventing at-risk patients being prescribed causative drugs. Improved...

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Anti-Bacterial Agents
Chemical and Drug Induced Liver Injury
Drug-Induced Hepatotoxicity and Protection
Genetic Predisposition to Disease
Genome-Wide Association Study

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PMID: 39704445
DOI: 10.1111/liv.16191
PMCID: PMC11660537

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