Article

Tumor-associated chromosomal instability drives progression of colorectal adenoma to adenocarcinoma: evidence from 17-year follow-up after adenoma diagnosis

2024-08-26

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. Adenomas, precursors to CRC, can be diagnosed early, but the genetic events leading to adenoma–adenocarcinoma conversion remain unclear. This study explored the role of chromosomal instabilities (CINs) in this conversion. Method Over a 17-year follow-up period, 119 adenomas were analyzed using low...

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Literature Corpus work: 362d2117-5cf3-5ff7-97be-9102734bbdd1
DOI: 10.21203/rs.3.rs-4759082/v1

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