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Article

Evolution of colorectal cancer: change of pace and change of direction.

Journal of gastroenterology and hepatology - 1 Jan 2002

Jass Jereny R, Young Joanne, Leggett Barbara A

Abstract excerpt

This review compiles evidence for an alternative to the classical adenoma-carcinoma sequence in the evolution of colorectal cancer. It is suggested that between 30 and 50 of colorectal cancers are not initiated by mutation of the tumor suppressor gene APC, but through the epigenetic silencing of genes implicated in the control of differentiation, cell cycle control and DNA repair proficiency. The precursor polyps...

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Identifiers

PMID: 11987262
DOI: 10.1046/j.1440-1746.2002.02635.x

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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