More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

doi:10.1016/j.neurobiolaging.2015.04.012

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Article

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

Neurobiology of aging - 1 Aug 2015

Rosenthal Samantha L, Bamne Mikhil N, Wang Xingbin, Berman Sarah, Snitz Beth E, Klunk William E, Sweet Robert A, Demirci F Yesim, Lopez Oscar L, Kamboh M Ilyas

Abstract excerpt

Over 20 risk loci have been identified for late-onset Alzheimer's disease (LOAD), most of which display relatively small effect sizes. Recently, a rare missense (R47H) variant, rs75932628 in TREM2, has been shown to mediate LOAD risk substantially in Icelandic and Caucasian populations. Here, we present more evidence for the association of the R47H with LOAD risk in a Caucasian population comprising 4567 LOAD...

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Identifiers

PMID: 26058841
DOI: 10.1016/j.neurobiolaging.2015.04.012
PMCID: PMC4465085

Genes

TREM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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