Article
TREM2 risk variants and associated endophenotypes in alzheimer's disease.
Alzheimer's research & therapy - 6 Mar 2025
Dijkstra Janna I R, Vermunt Lisa, Venkatraghavan Vikram, Ozhegov Georgii, Coomans Emma M, Ossenkoppele Rik, van de Giessen Elsmarieke, Hulsman Marc, de Geus Christa M, van der Flier Wiesje M, Sikkes Sietske A M, Barkhof Frederik, Tijms Betty, Gouw Alida A, de Haan Willem, Vijverberg Everard G B, Pijnenburg Yolande A L, Holstege Henne, Teunissen Charlotte E, van der Lee Sven J
Abstract excerpt
BACKGROUND: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer's disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. METHODS: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carriers (n = 123,...
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