Article
TREM2 is associated with increased risk for Alzheimer's disease in African Americans.
Molecular neurodegeneration - 10 Apr 2015
Jin Sheng Chih, Carrasquillo Minerva M, Benitez Bruno A, Skorupa Tara, Carrell David, Patel Dwani, Lincoln Sarah, Krishnan Siddharth, Kachadoorian Michaela, Reitz Christiane, Mayeux Richard, Wingo Thomas S, Lah James J, Levey Allan I, Murrell Jill, Hendrie Hugh, Foroud Tatiana, Graff-Radford Neill R, Goate Alison M, Cruchaga Carlos, Ertekin-Taner Nilüfer
Abstract excerpt
BACKGROUND: TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer's disease (LOAD) in Caucasians of European and North-American origin. This study evaluated the role of TREM2 in LOAD risk in African-American (AA) subjects. We performed exonic sequencing and validation in two independent cohorts of >800 subjects. We...
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