Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Determinants in HIV-1 Vif and Human APOBEC3 Proteins Are Required for the Suppression of Diverse Host Anti-Viral Proteins

16 Dec 2008

Abstract excerpt

BACKGROUND: APOBEC3G (A3G) and related cytidine deaminases of the APOBEC3 family of proteins are potent inhibitors of many retroviruses, including HIV-1. Formation of infectious HIV-1 requires the suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through the common mechanism of recruiting the Cullin5-ElonginB-ElonginC E3 ubiquitin ligase to induce target protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19088851
DOI: 10.1371/journal.pone.0003963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Determinants in HIV-1 Vif and Human APOBEC3 Proteins Are Required for the Suppression of Diverse Host Anti-Viral ProteinsPMID 19088851Read ↗

Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional ActivitiesSemantic proximity Read ↗

Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1.Semantic proximity Read ↗

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them AllSemantic proximity Read ↗

Cytidine Deaminases as a Weapon Against Retroviruses and a New Target for Antiviral TherapySemantic proximity Read ↗

Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.Semantic proximity Read ↗

Multifaceted HIV‐1 Vif interactions with human E3 ubiquitin ligase and APOBEC3sSemantic proximity Read ↗

Identification of an APOBEC3G Binding Site in Human Immunodeficiency Virus Type 1 Vif and Inhibitors of Vif-APOBEC3G BindingSemantic proximity Read ↗

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancerSemantic proximity Read ↗

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous RetroelementsSemantic proximity Read ↗

Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactionsSemantic proximity Read ↗

[Mechanisms for inhibition of retrovirus replication by APOBEC3 family].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.